WHAT'S THE DIFFERENCE BETWEEN SMOKE AND VAPOR? Vape Domain Moffitt experts note that switching to vaping may reduce harm for people who smoke, but it's not risk free, and the safest choice is still not to start. Balancing two priorities is key Why Do People Vape? What Drives People to Puff ? () Although often promoted as safer than traditional cigarettes, e cigarettes still harm the body in many ways. 1. Health Risks Most vapes contain nicotine, Vaping vs. smoking: Long term effects, benefits, and risks