Subcutaneous Injection: What It Is and How to Give One B12 Shots at Home: How, Where & How Often to Inject Yourself AZ IV Medics Subcutaneous (SC) and Intramuscular (IM) Injections Must Knows for Subcutaneous administration: Pinch skin with non dominant hand and hold syringe with dominant hand Always inject: 2 inches away from umbilicus (for abdomen) 3 inches Best Vitamin B12 Injection Sites: Where to Inject B12 PA Relief Is intramuscular (IM) administration of vitamin B12 injections preferred over subcutaneous (SC) administration?