Glutathione is a natural antioxidant your body makes, and it can influence melanin production which is why its sometimes marketed for skin brightening., Oral supplements are mostly broken down in Natural Ways to Increase Glutathione Before Wedding Glutathione Benefits for Gut Health Nikki Yelton RD Supplements to Increase Glutathione in the Body? Office for Science and Society McGill University Glutathione: your body's master antioxidant & detoxifier Glutathione is the 2nd most abundant molecule in the body, just after water. Its made from three amino acids: glycine, cysteine, & glutamate.