You may have seen the acronym MTHFR, which stands for methylenetetrahydrofolate reductase. This is an enzyme that plays a role in processing the nutrient folic acid folate into a form the body can B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline ScienceDirect The Role of MTHFR in Thyroid Conditions: A Deep Dive into the Connection MTHFR Support Australia Homocysteine: Diagnostic Significance and Clinical Insights Advanced Health Academy The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.