Acetaminophen (Tylenol) is widely used and generally safe when taken as directed. However, in overdose and chronic high dose use, or when combined with alcohol, it can cause liver damage. This Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Glutathione Injection: Cost, Benefits, and Side Effects Acetaminophen Toxicity: What Pharmacists Need to Know Acetaminophen toxicity EMCrit Project