Mechanism of paracetamol toxicity NUS Faculty of Science NUS Faculty of Science The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets Guangwen Luo, Lili Huang, Zhaowei Zhang, 2023 Figure 1: CMAJ Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body