Understanding Melanosis Eye: Symptoms, Causes, and Treatments Northwest Eye Medical vocabulary: What does Hutchinson's Melanotic Freckle mean YouTube Melanotic Neuroectodermal Tumor of Infancy MD Searchlight Neurocutaneous Melanosis (Neurocutaneous melanocytosis) Dermatology Advisor Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells.