Full article: Paracetamol: overdose induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect