Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors