Autism, Acetaminophen (Tylenol) & Oxidative Stress William Parker 248 Tylenol can lower the body's key antioxidant, glutathione, though this isn't seen on routine labs. But mechanistic data clinical proof, so we still need good trials. The Tylenolautism link isn't clear. Tylenol, Autism, and Leucovorin: What Parents Need to Know. The recent discussion about acetaminophen (Tylenol) and autism has raised understandable concerns, but decades of high quality research is clear acetaminophen use during pregnancy does not cause autism. While the causes of Evidence that acetaminophen triggers autism in susceptible individuals has been ignored and mishandled for more than a decade.