Parents ask me this all the time: Motrin or Tylenol for fever? Here's my pediatric naturopathic perspective: Motrin treats inflammation, which often drives fever It lasts longer, so fewer doses Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism Hidden Risks of NSAIDs, Tylenol, Steroids & Opioids Denver Sports and Holistic Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Sex differences in glutathione metabolism and acetaminophen toxicity