Oxidative Stress in Healthy and Pathological Red Blood Cells Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents ScienceDirect Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage Haematologica