How to Give a B12 Injection: Step By Step Instructions B12 Injection sites + How to use B12 Shots Safely How to self inject intramuscular vitamin B12 Overview Guy's and St Thomas' NHS Foundation Trust Does size matter? Historically, a bigger needle gauge was considered better to prevent damage to red blood cells. However, our recent guidelines recommend using smaller gauge needles (2325 G) for all Guide to Needle Size Poster
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