Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione: The Master Antioxidant Core Med Science Glutathione: Cng Dng, Liu Dng, Tc Dng Ph Kiehl's Glutathione: The Master Antioxidant Core Med Science Vin ung trng da Glutathione v nhng tc dng khng ng