The role of glutathione S transferase in anti cancer drug resistance Oncogene Glutathione catalysis and the reaction mechanisms of glutathione dependent enzymes ScienceDirect GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Drug Metabolism: Phase I and Phase II Metabolic Pathways IntechOpen PPT Drug metabolism PowerPoint Presentation, free download ID:2312754
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glutathione conjugation reaction 16 Phase II reactions Conjugation with GSH paracetamol