ACETAMINOPHEN INDUCED HEPATOTOXICITY Drug Metabolism and Disposition Since everyone is talking about Tylenol let's actually talk about Tylenol. No, it doesn't cause autism But here's what it can do: Deplete glutathione: one of your body's most Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Glutathione, Tylenol & Your Health: What You Should Know