Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Tylenol's Impact on Glutathione and Liver Damage Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network Frontiers Potential adverse actions of prenatal exposure of acetaminophen to offspring Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.