Condensation and Hydrolysis Reactions (M12Q6) CHEM 104: Working Copy Mechanistic investigations of the hydrolysis of amides, oxoesters and thioesters via kinetic isotope effects and positional isotope exchange ScienceDirect Enzymatic Hydrolysis of Tertiary Amide Bonds by anti Nucleophilic Attack and Protonation The Journal of Organic Chemistry Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems Scientific Reports Reactions of Amides a) Hydrolysis Amides can break back into the acid and amine when heated with: Strong acid Strong base Example: Amide + HO Carboxylic acid + Amine b) Reduction