Glutathione is one of the most important molecules in detoxification. It drives Phase II conjugation and helps neutralize oxidative stress at the cellular level. But detoxification does not end with transformation. It What is Glutathione? GoldBio TJ. Glutathione peroxidase is an important enzyme in cellular antioxidant defense systems, detoxifying peroxides and hydroperoxides. As a component of the glutathione cycle, it protects the liver from reactive oxygen metabolites. Selenocysteine Frontiers Case report: A Chinese patient with glutathione synthetase deficiency and a novel glutathione synthase mutation Substrate Profiling of Glutathione Stransferase with Engineered Enzymes and Matched Glutathione Analogues Feng 2014 Angewandte Chemie International Edition Wiley Online Library