The FDA is signaling that perhaps immediate treatment with acetaminophen is less clearly needed for a low grade fever, especially in pregnancy, unless theres a stronger indication for it., Safer Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Clinical toxicity of Acetaminophen Xia & He Publishing Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect