Brain health depends on balance. From energy production to antioxidant protection and immune regulation, multiple systems work together to support how the brain functions. Glutathione plays a central role in maintaining Frontiers Glutathione metabolism as a key regulator of oxidative hippocampal injury in sepsis associated encephalopathy: an integrated proteomics and metabolomics study Frontiers Glutathione deficiency in the pathogenesis of SARS CoV 2 infection and its effects upon the host immune response in severe COVID 19 disease Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Ferroptosis in central nervous system injuries: molecular mechanisms, diagnostic approaches, and therapeutic strategies