An interesting finding in melanocytic nevus that may alarm a pathologist and prompt a thorough search for other features of melanoma Herniation of a nevus nest into the lumen of Melanocytic lesions displaying peripheral dots and globules may raise diagnostic uncertainty when identified beyond adolescence. This is a trunk lesion in a 46 year old patient with no personal history of melanoma. Would you Histopathological Findings of a Melanocytic Nevus A melanocytic nevus is a benign proliferation of melanocytes. Under the microscope, typical features include: Nests or clusters of uniform melanocytes located at the dermoepidermal junction, Cellular encapsulation and melanization are enhanced by immulectins, pattern recognition receptors from the tobacco hornworm Manduca sexta ScienceDirect Insect phenoloxidase and its diverse roles: melanogenesis and beyond Journal of Comparative Physiology B Springer Nature Link