Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect Did you know acetaminophen lowers glutathione levels? Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol & Glutathione What Parents Need to Know! , I get it, many parents are concerned about giving their child Tylenol (acetaminophen) because it can lower glutathione, a crucial antioxidant that Actress and longtime anti vaccine activist Jenny McCarthy took to social media to weigh in on recent debates about acetaminophen (Tylenol), vaccines, and autism, sharing her concerns about glutathione