Frontiers LL37 driven mast cell degranulation and inflammation in rosacea via TLR2 JAK2 STAT3 axis The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers Frontiers LL37 driven mast cell degranulation and inflammation in rosacea via TLR2 JAK2 STAT3 axis Most people diagnosed with MCAS didn't develop it overnight. Their mast cells were dysregulated long before symptoms appeared. Early life exposures, such as environmental toxins, infections, and even implants, can alter how mast Tetraspanins in the regulation of mast cell function Medical Microbiology and Immunology Springer Nature Link