Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Can Tylenol (acetaminophen) deplete glutathione levels in the body? Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower