Phospholipase Inhibitors MedChemExpress When a signaling molecule, such as a hormone, binds to a Gq coupled receptor on the cell surface, it activates a G protein of the Gq type. This, in turn, activates an enzyme The Cryptococcal Enzyme Inositol Phosphosphingolipid Phospholipase C Confers Resistance to the Antifungal Effects of Macrophages and Promotes Fungal Dissemination to the Central Nervous System Infection and Immunity DAG and IP (B), Phosphatidylinositol 4,5 bisphosphate (PIP) is cleaved by phospholipase C following activation of Gq coupled receptors. This reaction produces diacylglycerol (DAG), which remains in Phospholipase C Creative Enzymes