Frontiers Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders HERPES VIRUSES reactivation Sequence of events** When a person is suffering from chronic stress, excess Cortisol and Adrenaline with lowered Glutathione. Glutathione is the body's most important antioxidant. Insufficient Glutathione reduces the EpsteinBarr virus infection controls the concentration of the intracellular antioxidant glutathione by upregulation of the glutamate transporter EAAT3 in tumor cells TMEFF1 is a neuron specific restriction factor for herpes simplex virus Nature Herpesviruses Glycopedia