I'm Dr Ashley Mayer . I'm a practicing integrative physician, and also a mama to two great kiddos of my own! If you caught my post on Ibuprofen a few days ago, DRUG AND TOXIN INDUCED HEPATITIS: ACETAMINOPHEN: Acetaminophen is converted by the hepatic cytochrome P 450 drug metabolizing system to a potentially toxic metabolite that is subsequently rendered harmless through conjugation with glutathione. When Reduced Glutathione 250 mg with Vitamin C and Selenium Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY