Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which N acetylcysteine (NAC) g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram About Acetaminophen Overdose Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health