HMP Pathway Simplified: NADPH Role & G6PD Deficiency Explained Frontiers Glucose 6 Phosphate Dehydrogenase Deficiency and Neonatal Hyperbilirubinemia: Insights on Pathophysiology, Diagnosis, and Gene Variants in Disease Heterogeneity Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz Pediatrics #12 MEHLMANMEDICAL File:Glutathion metabolism DE state in G6PD deficiency.png Wikimedia Commons