Invisible Pain Series: Mast Cell Activation Syndrome POGO Physio Gold Coast Calming the Chaos: How Ozone and Light Therapy Help with Mast Cell Activation Syndrome (MCAS) in Oklahoma City Venturis Clinic Mast Cell Activation Syndrome and Its Impact on the Lymphatics L Glutathione reduced Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.