Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus Pigmented macular lip lesion Clinical Advisor This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Summit Enlighten Laser to treat labial melanotic macules on the lip before and after. Facebook Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review