L Carnitine is Underrated. New Meta Review Reminds Us Why. Frontiers Dietary supplementation with L carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non mitochondrial respiration of bovine blood cells during systemic immune challenge Combined metabolic activators to treat mitochondrial dysfunction Mitochondrial dysfunction is a common feature of many human diseases and is emerging as a therapeutic target. Systems biology and multiomics approaches have revealed that l Carnitine reduces reactive oxygen species endoplasmic reticulum stress and maintains mitochondrial function during autophagy mediated cell apoptosis in perfluorooctanesulfonate treated renal tubular cells Scientific Reports A schematic diagram of the metabolic roles of carnitine in skeletal Download Scientific Diagram