Taking Ibuprofen? Protect Your Health With These Tips Dr. Green Mom Drugs for Pain, Inflammation, and Arthritic Disorders Basicmedical Key Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health I'm Dr Ashley Mayer . I'm a practicing integrative physician, and also a mama to two great kiddos of my own! If you caught my post on Ibuprofen a few days ago, Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.