Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought? Why patients taking enzyme Inducers and patients with anorexia nervosa experience higher risk of paracetamol toxicity?? Acetaminophen (Paracetamol) is extensively metabolized by the liver via three main hepatic pathways: glucuronidation, sulfation, Acetaminophen NAPQI Toxicity RK.MD 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Acetaminophen metabolism. Acetaminophen is metabolized primarily by Download Scientific Diagram