Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Acute acetaminophen paracetamol toxicity