Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer PNAS Metabolic orchestration driven by GGCT: diverting glutamine to glutathione biosynthesis while enhancing glucose anaplerosis for tumor proliferation Cell Death & Disease Glutamine Metabolism in Cancer Springer Nature Link Pan Cancer Metabolic Signature Predicts Co Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High Mesenchymal Cell State: Cell Metabolism What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it