How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Proposed acidic degradation pathway of GHKCu in acidic solution. Download Scientific Diagram Relief of ovalbumin induced airway remodeling by the glycyl l histidyl l lysine Cu2+ tripeptide complex via activation of SIRT1 in airway epithelial cells ScienceDirect The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling: Molecular Cell