Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Paracetamol toxicity Deranged Physiology Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Acetaminophen (N aetylpara aminiphenol) (APAP)Toxicity