Glutathione vs. NAC: Which Antioxidant Is Best for Your Liver? Life Extension Individuals with MTHFR mutations and slow COMT activity can generally take N acetylcysteine (NAC) and glutathione, but there are some important considerations: ## N Acetylcysteine (NAC) * **Benefits**: NAC supports the production of glutathione, Amazon.com: Advanced Complex NAC Supplement (N Acetyl L Cysteine) 600mg with L Glutathione 500mg and Milk Thistle Extract Potent Antioxidant Immune Function Support Respiratory Health Promotes Liver Kidney Detox : Health & Household Amazon.com: 2 Pack NAC Supplement (N Acetyl Cysteine) 1,000mg Serving with Reduced Glutathione, 480 Capsules : Health & Household L Glutathione VS NAC: Differences, Similarities, and Uses