Homocysteine: Genetics, High Homocysteine Levels, and Solutions Glutathione synthetase deficiency MedLink Neurology Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione Researchers discover cause of a new rare genetic condition: Glutamine synthetase stabilization disorder Glutathione: pharmacological aspects and implications for clinical use Geriatric Care