Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted AngIV Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP PS1 Mouse via the PI3K AKT Signaling Pathway Top Dihexa is a synthetic peptide known for its potential cognitive benefits by promoting nerve growth factor (NGF) activity, which supports the growth, maintenance, and survival of neurons in the brain. Synapse (Dihexa) Cognitive Peptide Therapy Lincoln Park Better Med Spa Peptides for Mental Health & Cognitive Function (2026)