5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. N Acetylcysteine: An Old Drug With Variable Anti Influenza Properties Semantic Scholar Full article: Perioperative N acetylcysteine: evidence and indications How do glutathione and Nacetylcysteine (NAC) compare regarding indications, dosing, effectiveness, and safety for acetaminophen toxicity, mucolytic therapy, and general antioxidant supplementation? What is NAC and what is Glutathione?