Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health What is Acetaminophen Uses, Dangers, Risks, & More Rubicon Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.