Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast cell activation syndrome, neck pain and the vagus nerve Mast cells: A dark horse in osteoarthritis treatment Glutathione Reductase from bakers yeast (S. cerevisiae) IRE1 determines ferroptosis sensitivity through regulation of glutathione synthesis Nature Communications