Peripheral artery disease (PAD) is the narrowing or blockage of blood vessels that run from the heart to other parts of the body. Smoking can cause PAD. Quit smoking to protect your Electronic Nicotine Delivery Systems and Cardiovascular Cardiometabolic Health Circulation Research Is Vaping Better Than Smoking? American Heart Association Electronic cigarettes and cardiovascular disease: epidemiological and biological links Pflgers Archiv European Journal of Physiology Springer Nature Link Nicotine free e cigarettes can damage blood vessels