Metabolic activation pathway of acetaminophen. Generally, NAPQI is Download Scientific Diagram Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification N acetylcysteine (NAC) Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect